Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

OMSs and reactivity in confined medium

Elaboration of bioinspired catalytic self-assemblies

The goal of this project is to benefit from the containment of molecules in and on the surface of OMSs to control and optimize their reactivity in water.

This system is especially suitable for hydrophobic molecules. In this context we develop OMSs derived from functional amphiphiles. They are used for their catalytic properties at the interfaces. The systems are developed within a sustainable approach (molecular economy and bio-inspired systems). OMSs derived from organoboron or oxime functionalized surfactants are used as nanoreactors in micellar catalysis for selective chemical decontamination of pesticides or chemical warfare.

Containment at the interfaces of OMS is also used for interfacial catalysis. For example, the OMSs issued from labile lipopeptides synergize the effects of a bio-inspired organocatalysis and an interfacial catalysis.
Examples of bio-inspired organocatalysis

This containment will also be used in interfacial photocatalysis to repair DNA damage via the synthesis and formulation of a photolyase mime.
Photolyase mimic and formulation


>> EPR spectroelectrochemical investigation of guanine radical formation and environment effects
J. Phys. Chem. B, 2014, 118, 2360-2365
Ribaut C .; Bordeau G. ; Perio P. ; Reybier K. ; Sartor V. ; Reynes O. ; Fabre P.L. ; Chouini-Lalanne N.

>> Synthesis, self-assembly, and catalytic activity of histidine-based structured lipopeptides for hydrolysis reactions in water
RSC Adv., 2015, 5, 35830-35842
Bélières M. ; Chouini-Lalanne N. ; Déjugnat C.

>> Histidine-based lipopeptides enhance cleavage of nucleic acids: interactions with DNA and hydrolytic properties
Bioconjugate Chemistry, 2015, 26 (12), 2520-2529
Belieres M. ; Dejugnat D. ; Chouini-Lalanne N.

2019 IMRCP