Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

Séminaire par Pr Ulrich S. Schubert / Université de Friedrich Schiller de Jena - Allemagne

Mercredi 27 juin 2018 - 14h - salle Maroni / MHT

Pr Ulrich S. Schubert, chercheur au Laboratoire de chimie organique et macromoleculaire à Jena (Allemagne) fera une présentation sur : New synthetic polymers and nanoparticles for applications in nanomedicine

Polymers feature a great potential for the delivery of various active pharmaceutical ingredients. An optimum carrier material should be non-toxic, bind and protect its cargo from degradation, be invisible to the immune system and direct cargo to its desired place of action. Although promising polymers exist to fulfill one or two of the requirements, only few are currently exploited for these purposes.
With focus on inflammation-related diseases, the lecture provides an overview about how traditional polymers can be modified, coupled to relevant building blocks, or be replaced by more tailor-made alternatives. In particular the solution self-assembly behavior of the (block co) polymers has to be studied in detail (e.g. by analytical ultracentrifugation, AF4, (cryo)TEM or others).

 

References : Angew. Chem. Int. Ed. 2018, 57, 2479; Biomacromolecules 2018, 19, 748; Biomacromolecules 2017, 18, 3280; Polym. Chem. 2017, 8, 6086; Polym. Chem. 2017, 8, 1328; Anal. Chem. 2017, 89, 1185

2018 IMRCP