Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

Séminaire par Dr Morgan Delarue / LAAS

lundi 4 juin 2018 - 14h - salle Maroni / MHT

Dr Morgan Delarue, chercheur au LAAS fera une présentation sur : Cells under pressure: from direct mechanosensing to indirect consequences

Cells act upon the elastic extracellular matrix and against steric constraints when growing in a spatially limited environment. At the multicellular level, confined cell proliferation results in the emergence of a compressive, growth-induced, mechanical stress. Compressive stresses are ubiquitous to any cell population developing in confinement, such as most solid tumours or microbes. In this talk, I will present microfluidic devices that enabled recent discoveries on the impact and on the integration of compressive mechanical stresses. I will discuss mechanosensitive pathways recently unravelled in the budding yeast S. cerevisiae that are essential for cell survival, as well as how modification of cellular biophysical properties can indirectly affect cell physiology.

2018 IMRCP