Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

Formulation of OMSs for drug delivery

Design of drug delivery systems from renewable resources and decryption of their interactions with biological systems.

We develop formulations / drug delivery systems which are consistent with sustainable development, using a “green” galenic original approach. The challenge lies therefore in the design of versatile drug delivery systems, easily tunable according to the drug that has to be encapsulated and delivered as well as to the biological target.

Electronic microscopy of catanionic vesicles and assembly mode

In this context, we take benefit of the unique properties of catanionic surfactants which have the ability to spontaneously form vesicles in order to elaborate new drug delivery systems. The understanding of the mechanism of interaction between vectors and cells, as well as the encapsulated drug release mode is one of our main concerns, so we can adapt the vector to the desired application.
Based on the principle of molecular economy, the bio-active formulation concept consists in making the drug participate to its own transport. The originality lies in the fact that the drug is not passively carried by a vector, but it intrinsically participates to the self-assembly of the carrier and therefore is an ingredient of its own formulation.

Example of a vesicle formed by a bioactive ion pair

Several formulations based on this concept have been patented and marketed along with Pierre Fabre Laboratories and the CNRS (TriXera+ Sélectiose® and TriAcneal®) for dermatology care.

We also develop colloidal aqueous dispersions of organogel (see axe 4) nanoparticles. These vectors based on vegetable oils and natural gelators integrate perfectly our “green” galenic approach, and are particularly suited to encapsulate hydrophobic drugs.

MET de nanoparticules d’organogels
 

>> Versatile Cellular Uptake Mediated by Catanionic Vesicles: Simultaneous Spontaneous Membrane Fusion and Endocytosis
Mol. Pharmaceutics, 2015, 12, 103-110
Mauroy C. ; Castagnos P. ; Orio J. ; Blache M.C. ; Rico-Lattes I. ; Teissié J. ; Rols M.P. ; Blanzat M.
 
>> Evaluation of Organogel Nanoparticles as Drug Delivery System for Lipophilic Compounds
AAPS PharmSciTech, 2016, 1-9
 

>> Green microparticles based on a chitosan/lactobionic acid/linoleic acid association. Characterisation and evaluation as a new carrier system for cosmetics
Journal of Microencapsulation, 2017, 34 (2), 162-170
Chaouat C. ; Balayssac S. ; Malet-Martino M. ; Belaubre F. ; Questel E. ; Schmitt A.-M. ; S. Poigny S. ; Franceschi S. ; Perez E.

2018 IMRCP