Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

Polymeric nanomaterials

 

Temperature- or light-responsive polymers with controlled architectures (linear, branched or hyperbranched structures) are synthetized or chemically modified to get self-assemblies such as hydrogels, micelles, polymersomes, emulsions
These assemblies have applications for drug delivery, photocatalytic water treatment or act as nanoreactors.
Two examples of this research are described below:

Polymer self-assemblies in Cancer Phototherapy

Polymer micelles transporting photosensitizers are used for killing 3D tumor models by photodynamic therapy. The therapeutic efficiency depends on the architecture of the polymer assembly and has been shown to increase with crosslinking.

Crosslinked polymeric self-assemblies as an efficient strategy for photodynamic therapy on a 3D cell culture
RSC Adv., 2016, 6, 69984-69998
Till U. ; Gibot L. ; Vicendo P. ; Rols M.P. ; Gaucher M. ; Violleau F. ; Mingotaud A.F.

A shear-induced network of aligned wormlike micelles in a sugar-based molecular gel. From gelation to biocompatibility assays

A new molecular hydrogelator was prepared by click chemistry from a lactose-derived carbohydrate and an alkylamide. In water, it self-assembles spontaneously into long twisted fibers. Additionally, the application of a strong shear induces the formation of large self-assembled sheets made of long cylindrical micelles aligned side-by-side. The entanglement of these sheets forms a network sustaining the formation of a hydrogel.

A shear-induced network of aligned wormlike micelles in a sugar-based molecular gel. From gelation to biocompatibility assays.
Journal of Colloid and Interface Science, 2017, 504, 721–730
Fitremann J. ; Lonetti B. ; Fratini E. ; Fabing I. ; Payré B. ; Boulé C. ; Loubinoux I. ; Vaysse L. ; Oriol L.

2017 IMRCP