Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

MAPES team / V. Poinsot

 
The expertise of our team lies in its mastery of methods for isolation of biomolecules by bioguided strateges. Another major focus of the group is the structural identification and semi-quantitative analysis of biomolecules using various complementary analytical techniques.

Isolation and identification of bioactive molecules

We isolate and identify bioactive molecules in order to understand their mode of action.
We study living organisms ranging from bacteria to plants through human or mycorrhizae ... With biological screening techniques associated with the observation of the targeted activity, we identify:
> chemical messengers of agronomic interest (factors and mycorrhization nodulation factors)
> and mediators involved in the recognition between cells such cancer cell lines (ovary, lymphocytes, ...) and macrophages.

The compounds that we characterize are usually complex sugars, lipids or peptides.
The aim is to highlight the one hand natural substances for economically viable applications in a sustainable development approach and also to understand the interactions leading to severe pathologies opening new therapeutic avenues.

New applications for capillary electrophoresis

We develop new fields of application for capillary electrophoresis. For example: the selection of aptamers with high throughput sequencing or the study of amino acids as depression and diabetes markers.
The aim is to develop two local SMEs specialized in this field of analysis (Winsep and Picometrics).
 
2017 IMRCP