Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique
UMR 5623

Polymeric nanomaterials

 

Temperature- or light-responsive polymers with controlled architectures (linear, branched or hyperbranched structures) are synthetized or chemically modified to get self-assemblies such as hydrogels, micelles, polymersomes, emulsions
These assemblies have applications for drug delivery, photocatalytic water treatment or act as nanoreactors.
Two examples of this research are described below:

Polymer self-assemblies in cancer phototherapy

Upon irradiation, the photosensitizer pheophorbide-a encapsulated in a copolymer nanocarrier causes dramatic morphological transitions in giant unilamellar lipid vesicles thorugh an endocytosis-like process.

Extended photo-induced endosome-like structures in Giant Vesicles promoted by block-copolymer nanocarriers
Nanoscale, 2018, 10, 15442-15446
Montis C. ; Till U. ; Vicendo P. ; Roux C. ; Mingotaud A.-F. ; Violleau F. ; Demazeau M. ; Berti D. ; Lonetti B.

 

Synthetic molecular hydrogels as scaffold for 3D neuronal cell growth

Molecular hydrogels based on a very simple molecule, N-heptyl-galactonamide, enable the growth of human adult neural stem cells. They form a dense network of glial cells and neurons with many highly developed neurites of various morphologies.

Simple Synthetic Molecular Hydrogels from Self-Assembling Alkylgalactonamides as Scaffold for 3D Neuronal Cell Growth
ACS Applied Materials & Interfaces, 2018, 10, 17004-17017
Chalard A. ; Vaysse L. ; Joseph P. ; Malaquin L. ; Souleille S. ; Lonetti B. ; Sol J.-C. ; Loubinoux I. ; Fitremann J.

2018 IMRCP